obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
| Name | D3_CVID |
|---|---|
| Long name | Common variable immunodeficiency |
| Hospital Discharge registry | ICD-10: D83 |
| Cause of Death registry | ICD-10: D83 |
| Include | D3_CVID_BCELL, D3_CVID_TCELL, D3_CVID_BT_CELL_AB, D3_CVIDNAS |
| Level in the ICD-hierarchy | 3 |
| First defined in version | DF2 |
| Latin name | Deficientia immunalis variabilis communis |
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 96 | 67 | 29 |
| Unadjusted prevalence (%) | 0.04 | 0.05 | 0.03 |
| Mean age at first event (years) | 49.22 | 49.57 | 48.40 |
| Case fatality at 5-years (%) | 4.17 | 5.97 | 0.00 |
| All | Female | Male | |
|---|---|---|---|
| Median nb. of events per indiv. | 2.0 | 2.0 | 3.0 |
| Recurrence at 6 months (%) | 51.04 | 49.25 | 55.17 |
before Common variable immunodeficiency
after Common variable immunodeficiency
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