Villonodular synovitis (pigmented)

pigmented villonodular synovitis: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursae (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.

Endpoint definition

Name M13_VILLONODULAR
Long name Villonodular synovitis (pigmented)
Hospital Discharge registry ICD-10: M122
Cause of Death registry ICD-10: M122
Level in the ICD-hierarchy 4
First defined in version DF2
Latin name Synovitis villonodularis [pigmentata]

Summary Statistics

Key figures

All Female Male
Number of individuals 117 76 41
Unadjusted prevalence (%) 0.05 0.06 0.04
Mean age at first event (years) 40.64 39.28 43.17
Case fatality at 5-years (%) 0.00 0.00 0.00

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 1.0 1.0 1.0
Recurrence at 6 months (%) 15.38 10.53 24.39

Survival analyses between endpoints

Plot

before Villonodular synovitis (pigmented)
after Villonodular synovitis (pigmented)

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Drugs most likely to be purchased after Villonodular synovitis (pigmented)