Sicca syndrome [Sjögren]

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

Long name Sicca syndrome [Sjögren]
Hospital Discharge registry ICD-10: M350, ICD-8: 73490
Cause of Death registry ICD-10: M350, ICD-8: 73490
Level in the ICD-hierarchy 4
First defined in version DF2
Latin name Syndroma Sjögren

Summary Statistics

Key figures

All Female Male
Number of individuals 1290 1119 171
Unadjusted prevalence (%) 0.59 0.91 0.18
Mean age at first event (years) 53.34 52.95 55.94
Case fatality at 5-years (%) 2.09 1.88 3.51

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 2.0 2.0 1.0
Recurrence at 6 months (%) 48.68 50.49 36.84

Survival analyses between endpoints


before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

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Drugs most likely to be purchased after Sicca syndrome [Sjögren]