Coeliac disease

celiac disease: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

Endpoint definition

Name K11_COELIAC
Long name Coeliac disease
Hospital Discharge registry ICD-10: K900, ICD-9: 5790A
Cause of Death registry ICD-10: K900, ICD-9: 5790A
Level in the ICD-hierarchy 3
First defined in version DF2
Latin name Coeliacia

Summary Statistics

Key figures

All Female Male
Number of individuals 1973 1314 659
Unadjusted prevalence (%) 0.91 1.07 0.70
Mean age at first event (years) 45.91 44.47 48.79
Case fatality at 5-years (%) 1.62 0.99 2.88

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 2.0 2.0 2.0
Recurrence at 6 months (%) 47.24 47.34 47.04

Survival analyses between endpoints

Plot

before Coeliac disease
after Coeliac disease

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