myocarditis: Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus , Wegener's granulomatosis , giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and, rarely, a heart transplant may be needed if the heart muscle becomes weak. [ ]

Endpoint definition

Long name Myocarditis
Hospital Discharge registry ICD-10: I41/I40, ICD-9: 422, ICD-8: 0742|422
Cause of Death registry ICD-10: I41/I40, ICD-9: 422, ICD-8: 0742|422
Level in the ICD-hierarchy 4
First defined in version DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 829 328 501
Unadjusted prevalence (%) 0.38 0.27 0.53
Mean age at first event (years) 42.67 47.06 39.79
Case fatality at 5-years (%) 3.98 2.74 4.79

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 1.0 1.0 1.0
Recurrence at 6 months (%) 24.85 28.35 22.55

Survival analyses between endpoints


before Myocarditis
after Myocarditis

Loading survival analyses plot…