Otosclerosis

otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs.

Endpoint definition

Name H8_OTOSCLE
Long name Otosclerosis
Hospital Discharge registry ICD-10: H80, ICD-9: 387, ICD-8: 38699
Cause of Death registry ICD-10: H80, ICD-9: 387, ICD-8: 38699
Level in the ICD-hierarchy 3
First defined in version DF2
Latin name Otosclerosis

Summary Statistics

Key figures

All Female Male
Number of individuals 1350 874 476
Unadjusted prevalence (%) 0.62 0.71 0.51
Mean age at first event (years) 45.43 44.51 47.11
Case fatality at 5-years (%) 0.52 0.23 1.05

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 3.0 3.0 3.0
Recurrence at 6 months (%) 44.07 43.36 45.38

Survival analyses between endpoints

Plot

before Otosclerosis
after Otosclerosis

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