Thyrotoxicosis with diffuse goitre

Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Endpoint definition

Long name Thyrotoxicosis with diffuse goitre
Hospital Discharge registry ICD-10: E050, ICD-8: 2420
Cause of Death registry ICD-10: E050, ICD-8: 2420
Level in the ICD-hierarchy 3
First defined in version DF2
Latin name Thyreotoxicosis cum struma diffusa

Summary Statistics

Key figures

All Female Male
Number of individuals 2350 1959 391
Unadjusted prevalence (%) 1.08 1.59 0.42
Mean age at first event (years) 48.91 48.31 51.88
Case fatality at 5-years (%) 1.11 0.92 2.05

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 4.0 4.0 3.0
Recurrence at 6 months (%) 71.87 72.43 69.05

Survival analyses between endpoints


before Thyrotoxicosis with diffuse goitre
after Thyrotoxicosis with diffuse goitre

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Drugs most likely to be purchased after Thyrotoxicosis with diffuse goitre