Secondary lactase deficiency

lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Endpoint definition

Long name Secondary lactase deficiency
Hospital Discharge registry ICD-10: E731
Cause of Death registry ICD-10: E731
Level in the ICD-hierarchy 4
First defined in version DF2
Latin name Deficientia lactasae secundaria

Summary Statistics

Key figures

All Female Male
Number of individuals 14 8 6
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 41.58 36.79 47.97
Case fatality at 5-years (%) 0.00 0.00 0.00

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 1.0 1.0 1.0
Recurrence at 6 months (%) 14.29 12.50 16.67

Survival analyses between endpoints


before Secondary lactase deficiency
after Secondary lactase deficiency

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Drugs most likely to be purchased after Secondary lactase deficiency