hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

Long name Hyperparathyroidism
Hospital Discharge registry ICD-10: E213/E211/E212/E210, ICD-8: 2520
Cause of Death registry ICD-10: E211/E210/E213/E212, ICD-8: 2520
Medicine purchases: ATC codes H05B
Level in the ICD-hierarchy 4
First defined in version DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 2928 2236 692
Unadjusted prevalence (%) 1.35 1.82 0.74
Mean age at first event (years) 62.88 63.27 61.65
Case fatality at 5-years (%) 6.49 5.99 8.09

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 2.0 2.0 2.0
Recurrence at 6 months (%) 53.69 55.62 48.13

Survival analyses between endpoints


before Hyperparathyroidism
after Hyperparathyroidism

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Drugs most likely to be purchased after Hyperparathyroidism