Eosinophilia

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Endpoint definition

Name D3_EOSINOPHILIA
Long name Eosinophilia
Hospital Discharge registry ICD-10: D721
Cause of Death registry ICD-10: D721
Level in the ICD-hierarchy 4
First defined in version DF2
Latin name Eosinophilia

Summary Statistics

Key figures

All Female Male
Number of individuals 182 95 87
Unadjusted prevalence (%) 0.08 0.08 0.09
Mean age at first event (years) 53.38 51.70 55.22
Case fatality at 5-years (%) 2.20 2.11 2.30

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 1.0 1.0 1.0
Recurrence at 6 months (%) 41.21 43.16 39.08

Survival analyses between endpoints

Plot

before Eosinophilia
after Eosinophilia

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