Follicular lymphoma

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

Long name Follicular lymphoma
Hospital Discharge registry ICD-10: C82, ICD-9: 2000A
Cause of Death registry ICD-10: C82, ICD-9: 2000A
Level in the ICD-hierarchy 3
First defined in version DF4
Latin name Lymphoma non-Hodgkin nodulare (folliculare)

Summary Statistics

Key figures

All Female Male
Number of individuals 522 262 260
Unadjusted prevalence (%) 0.24 0.21 0.28
Mean age at first event (years) 61.89 61.49 62.30
Case fatality at 5-years (%) 7.28 6.11 8.46

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 7.0 7.0 7.0
Recurrence at 6 months (%) 75.86 74.81 76.92

Survival analyses between endpoints


before Follicular lymphoma
after Follicular lymphoma

Loading survival analyses plot…

Drugs most likely to be purchased after Follicular lymphoma