Crohn disease (strict definition, require KELA, min 2 HDR)

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

Name K11_CD_STRICT2
Long name Crohn disease (strict definition, require KELA, min 2 HDR)
Hospital Discharge registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Cause of Death registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Conditions required K11_KELACROHN&K11_CROHN_NEVT>1
Level in the ICD-hierarchy C
First defined in version DF3
Latin name Morbus Crohn

Summary Statistics

Key figures

All Female Male
Number of individuals 848 500 348
Unadjusted prevalence (%) 0.39 0.41 0.37
Mean age at first event (years) 40.06 40.20 39.85
Case fatality at 5-years (%) 0.71 0.60 0.86

Longitudinal metrics

All Female Male
Median nb. of events per indiv. 7.0 7.0 7.0
Recurrence at 6 months (%) 67.70 68.69 66.44

Survival analyses between endpoints

Plot

before Crohn disease (strict definition, require KELA, min 2 HDR)
after Crohn disease (strict definition, require KELA, min 2 HDR)

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Drugs most likely to be purchased after Crohn disease (strict definition, require KELA, min 2 HDR)